SINCE 1992
 
 
 

Our goal is to provide the best Customer Experience possible. If you cannot find what you are looking for, have any questions or would like to give us a suggestion please use any of the following ways to contact us directly. We would love to hear from you.

We are always ready to lend any support we can. Our experienced scientists and professionals are ready to assist you with any technical support questions. Every question is considered a good question and we will work with you on a solution as fast as possible.

For LC‑MS and HPLC Analysis of Extremely Polar Compounds

Diamond Hydride™ HPLC columns are MICROSOLV’s best‑selling and highest‑performing column, widely regarded as the gold standard for LC‑MS and HPLC analysis of very polar compounds. These columns are especially effective for ANP / HILIC style separations, combining strong polar retention with controlled hydrophobicity.

Diamond Hydride™ columns are the most popular choice for scientists working in LC‑MS, metabolomics, bioanalytical research, and the analysis of amino acids, organic acids, carbohydrates, and other highly polar small molecules.

Unique Silica Hydride Surface Chemistry (TYPE‑C™)

Diamond Hydride™ columns are based on a silica hydride surface, similar to other TYPE‑C™ phases, but with a critical enhancement that sets them apart. A very small, controlled amount of carbon is incorporated on the surface, precisely tuning the hydrophobicity of the stationary phase.

This unique surface chemistry provides:

  • Strong retention of extremely polar compounds

  • Controlled hydrophobic interactions

  • Improved peak shape and reproducibility

  • Enhanced performance in ANP / HILIC like methods

  • Exceptional compatibility with LC‑MS

The result is a versatile column that bridges polar and moderately non‑polar analytes more effectively than traditional silica‑based phases.

Ideal for Complex and Biological Matrices

Diamond Hydride™ columns allow precise, robust methods to be developed even when working with complex sample matrices, including biological fluids such as:

  • Plasma

  • Urine

  • Saliva

  • Other bio‑matrices

Both polar and some non‑polar peptides can often be separated in the same run, making Diamond Hydride™ a powerful tool for comprehensive profiling and untargeted analysis.

Applications Where Diamond Hydride™ Excels

  • LC‑MS and LC‑MS/MS

  • Metabolomics and lipid‑polar hybrid studies

  • Bioanalytical and clinical research

  • Amino acids and organic acids

  • Carbohydrates and sugars

  • Very polar small molecules

  • Mixed polar / non‑polar analyte separations

Key Features and Benefits

  • Best‑selling and best‑performing MICROSOLV column

  • Designed for extremely polar compounds

  • Optimized for LC‑MS and HPLC

  • Unique silica hydride TYPE‑C™ surface

  • Precisely tuned hydrophobicity

  • Excellent performance in ANP / HILIC methods

  • Enables separation of polar and some non‑polar analytes in one run

  • Reliable performance with complex biological samples

Learn More and Technical Resources

Column Protection Recommendation

Important: MICROSOLV technical support strongly recommends using the Cogent Column Filter, which is included with each column, whenever possible. Column filters help protect the column from particulates, extend column lifetime, and maintain consistent chromatographic performance.

👉Learn more about the Cogent Column Filter for HPLC column protection

Clear All Selections Clear All Selections Share mdi-content-copy
{{ pids.length }} PRODUCTS MATCHING
Toggle to view Images Toggle to view Table

© Copyright 2026. MICROSOLV. All Rights Reserved. Website & Hosting by BlueTone Media